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The research in our Cancer Data Science (CaDS) group is focused on understanding the complexity of cancer, both from the disease and the treatment perspective, through the computational analysis and integration of large-scale molecular datasets. More specifically, we are currently interested in improving cancer treatments with more personalized therapeutic approaches derived from computational methods, understanding the molecular mechanisms of the disease in younger patients, or applying computational approaches to unravel tumor cell lineages. We have also developed highly successful bioinformatics tools, such as SNPStats, and collaborate with multiple groups in our institution and other national and international research groups.
CANCER COMPUTATIONAL BIOLOGY, BIOINFORMATICS, PRECISION MEDICINE, SYSTEMS/NETWORK BIOLOGY, BIOLOGICAL DATA INTEGRATION, SIGNALING PATHWAYS AND MOLECULAR BIOLOGY, NEXT-GENERATION SEQUENCING ANALYSIS, MACHINE LEARNING, GENETIC EPIDEMIOLOGY, ASSOCIATION STUDIES, CANCER BIOMARKERS AND SUSCEPTIBILITY.

EDUCATION

2012 – Ph.D. Medicine, University of Barcelona (UB), Spain.

2003 – M.A.S. Genetics, University of Barcelona (UB), Spain.
2001 – B.Sc. Computer Science, Polytechnic University of Catalonia (UPC), Spain.

 

WORK EXPERIENCE

2017 – current: Collaborating Professor of the Master’s Degree in Clinical Research, Biostatistics I, International University of Catalonia (UIC), Barcelona

2016 – current: Leader of the Cancer Data Science Group (CaDS), Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Barcelona

2012 – 2016: Postdoctoral Research Fellow at Sridhar Ramaswamy’s Lab, Massachusetts General Hospital Cancer Center / Harvard Medical School / Broad Institute of MIT & Harvard, Boston, USA

2008: Visiting scientist at Andrea Califano’s Lab. Center for Computational Biology and Bioinformatics (C2B2), Columbia University, New York, USA

2008 – 2012: Computational biologist. Unit of Biomarkers and Susceptibility, Catalan Institute of Oncology (ICO), Barcelona

2001 – 2007: Computational biologist. Cancer Epidemiology and Registration Department, Catalan Institute of Oncology (ICO), Barcelona

 

OTHER

Awards and honors:

  • Postdoctoral Fellowship: Bolsas de Ampliación de Estudios (BAE), Acción Estratégica de Salud. Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness (2012).
  •  Training Fellowship: Yamagiwa-Yoshida Memorial International Study Grant, International Union Against Cancer (2008).
  •  Training Fellowship: Catalan Agency for Management of University and Research Grants (AGAUR) Travel Fellowship. Declined due to incompatibility with another awarded funding (2008).

 

Selected presentations in national and international meetings:

  • November 2016: Solé X, Salony, Alves CP, Dey-Guha I, Ritsma L, Boukhali M, Lee JH, Chowdhury J, Ross KN, Haas W, Vasudevan S, Ramaswamy S.  AKT Inhibition Promotes Non-autonomous Cancer Cell Survival. 1st PMPPC Conference: Personalized Cancer Medicine in the Age of Aging, Barcelona (Spain). Oral presentation.
  • October 2016: Solé X, Salony, Alves CP, Dey-Guha I, Ritsma L, Boukhali M, Lee JH, Chowdhury J, Ross KN, Haas W, Vasudevan S, Ramaswamy S.  AKT Inhibition Promotes Non-autonomous Cancer Cell Survival. 15th CRG Symposium: Evolution and Medicine, Barcelona (Spain). Oral presentation.
  • April 2016: Solé X, Salony, Alves CP, Dey-Guha I, Ritsma L, Boukhali M, Lee JH, Chowdhury J, Ross KN, Haas W, Vasudevan S, Ramaswamy S.  AKT Inhibition Promotes Non-autonomous Cancer Cell Survival. MGH SAC 2016, Boston (USA). Poster.
  • October 2011: Solé X, Cordero D, Crous-Bou M, Sanz R, Berenguer A, Moreno V. Master Regulators of Metastasis in Early Stage Colon Cancer. 6th Annual DREAM on Reverse Engineering Challenges, 7th Annual RECOMB Satellite on Systems Biology, 8th Annual RECOMB Satellite on Regulatory Genomics & 1st IDIBELL Conference on Cancer Informatics (RICCI), Barcelona (Spain). Oral presentation.

 

Memberships and other scientific contributions

–    2010 – Present: Member of the New York Academy of Sciences (NYAS).

–    2009 – Present: UICC Yamagiwa-Yoshida grant reviewer.

–    2008 – Present: Reviewer for BMC Bioinformatics, BMC Cancer, BMC Medical Genomics .

–    2002 – Present: member of the International Society for Computational Biology.

 

SELECTED PUBLICATIONS

JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers.

Facompre ND, Harmeyer KM, Solé X, Kabraji S, Belden Z, Sahu V, Whelan K, Tanaka K, Weinstein GS, Montone KT, Roesch A, Gimotty PA, Herlyn M, Rustgi AK, Nakagawa H, Ramaswamy S, Basu D. Cancer Res. 2016 Sep 15;76(18):5538-49. doi: 10.1158/0008-5472.CAN-15-3377. Epub 2016 Aug 3. PMID: 27488530.

 

AKT Inhibition Promotes Nonautonomous Cancer Cell Survival.

Salony*, Solé X*, Alves CP, Dey-Guha I, Ritsma L, Boukhali M, Lee JH, Chowdhury J, Ross KN, Haas W, Vasudevan S, Ramaswamy S. Mol Cancer Ther. 2016 Jan;15(1):142-53. doi: 10.1158/1535-7163.MCT-15-0414. Epub 2015 Dec 4. PMID: 26637368

 

Large differences in global transcriptional regulatory programs of normal and tumor colon cells.

Cordero D*, Solé X*, Crous-Bou M, Sanz-Pamplona R, Paré-Brunet L, Guinó E, Olivares D, Berenguer A, Santos C, Salazar R, Biondo S, Moreno V. BMC Cancer. 2014 Sep 24;14:708. doi: 10.1186/1471-2407-14-708. PMID: 25253512

 

Discovery and validation of new potential biomarkers for early detection of colon cancer.

Solé X*, Crous-Bou M*, Cordero D*, Olivares D, Guinó E, Sanz-Pamplona R, Rodriguez-Moranta F, Sanjuan X, de Oca J, Salazar R, Moreno V. PLoS One. 2014 Sep 12;9(9):e106748. doi: 10.1371/journal.pone.0106748. eCollection 2014 Sep 12. PMID: 25215506

 

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.

Della Gatta G, Palomero T, Perez-Garcia A, Ambesi-Impiombato A, Bansal M, Carpenter ZW, De Keersmaecker K, Solé X, Xu L, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Meijerink JP, Califano A, Ferrando AA. Nat Med. 2012 Feb 26;18(3):436-40. doi: 10.1038/nm.2610. PMID: 22366949