Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Genetic predisposition is an important determinant of colorectal cancer (CRC), as demonstrated by the elevated frequency of this disease within the affected families. Besides the several known driver mutations of the key genes implicated in the tumorigenesis, there are also common genetic polymorphisms implicated in CRC. Each of these polymorphisms confers a small increase in […]

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Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study

Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and […]

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Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study

A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. In this work we aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population […]

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Cancer causing human papillomavirus lineage originate by sexual transmission from Neanderthals

A new study from the Catalan Institute of Oncology has found that a particular papillomavirus lineage associated with anogenital cancers very likely originate through sexual transmission from archaic Neanderthals-Denisovans to modern humans. The study led by Ville Pimenoff at the Catalan Institute of Oncology and Ignacio Bravo at the French National Center for Scientific Research […]

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Altered pathways and colorectal cancer prognosis

The article Altered pathways and colorectal cancer prognosis, published at BMC Med journal  by Víctor Moreno and Rebeca Sanz-Pamplona, discusses the results published by Slattery et al. in the article “Improved survival among colon cancer patients with increased differentially expressed pathways”. The authors showed a differential gene expression analysis between tumor tissue and adjacent normal tissue based […]

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Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer

The article Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer has been published in Clinical Cancer Research journal. The main author is Rebeca Sanz, from  Cancer Prevention and Control Program at ICO. The main objective of the study was to characterize the colonomicst tumors at mutational level, by exome sequencing. After analyzing the results, one […]

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New publication: Mutanome and expression of immune response genes in microsatelite stable colon cancer

Recently, the paper Mutanome and expression of immune response genes in microsatellite stable colon cancer has been published in the Oncotarget journal. The first author is Rebeca Sanz, PhD in Biology, from the Cancer Prevention and Control Program. Also, Victor Moreno, Adriana Lopez-Doriga and Henar Alonso; among others, are listed as authors. The article Exome Sequencing […]

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Large differences in global transcriptional regulatory programs of normal and tumor colon cells

This article, published in BMC journal which is the main author David Cordero, shows how the dysregulation of transcriptional programs leads to cell malfunctioning and can have an impact in cancer development. This study aims to characterize global differences between transcriptional regulatory programs of normal and tumor colon cells. The results show that the tumor […]

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