Publicaciones 2021

Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids.

Devall MAM, Drew DA, Dampier CH, Plummer SJ, Eaton S, Bryant J, Díez-Obrero V, Mo J, Kedrin D, Zerjav DC, Takacsi-Nagy O, Jennelle LT, Ali MW, Yilmaz ÖH, Moreno V, Powell SM, Chan AT, Peters U, Casey G. Cancer Prev Res (Phila). 2021 Dec;14(12):1089-1100. doi: 10.1158/1940-6207.CAPR-21-0041. Epub: 2021 Aug 13. PMID: 34389629; PMCID: PMC8639779
The 40S-LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity.

Fuentes P, Pelletier J, Martinez-Herráez C, Diez-Obrero V, Iannizzotto F, Rubio T, Garcia-Cajide M, Menoyo S, Moreno V, Salazar R, Tauler A, Gentilella A. Sci Adv. 2021 Nov 26;7(48):eabg9275. doi: 10.1126/sciadv.abg9275. Epub: 2021 Nov 26. PMID: 34818049; PMCID: PMC8612684
Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.

Nounu A, Richmond RC, Stewart ID, Surendran P, Wareham NJ, Butterworth A, Weinstein SJ, Albanes D, Baron JA, Hopper JL, Figueiredo JC, Newcomb PA, Lindor NM, Casey G, Platz EA, Marchand LL, Ulrich CM, Li CI, van Dujinhoven FJB, Gsur A, Campbell PT, Moreno V, Vodicka P, Vodickova L, Amitay E, Alwers E, Chang-Claude J, Sakoda LC, Slattery ML, Schoen RE, Gunter MJ, Castellví-Bel S, Kim HR, Kweon SS, Chan AT, Li L, Zheng W, Bishop DT, Buchanan DD, Giles GG, Gruber SB, Rennert G, Stadler ZK, Harrison TA, Lin Y, Keku TO, Woods MO, Schafmayer C, Van Guelpen B, Gallinger S, Hampel H, Berndt SI, Pharoah PDP, Lindblom A, Wolk A, Wu AH, White E, Peters U, Drew DA, Scherer D, Bermejo JL, Brenner H, Hoffmeister M, Williams AC, Relton CL. Nutrients. 2021 Nov 21;13(11). doi: 10.3390/nu13114164. Epub: 2021 Nov 21. PMID: 34836419; PMCID: PMC8620763
Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer.

Obón-Santacana M, Díez-Villanueva A, Alonso MH, Ibáñez-Sanz G, Guinó E, López A, Rodríguez-Alonso L, Mata A, García-Rodríguez A, Palomo AG, Molina AJ, Garcia M, Binefa G, Martín V, Moreno V. BMC Med. 2021 Nov 8;19(1):261. doi: 10.1186/s12916-021-02134-x. Epub: 2021 Nov 8. PMID: 34743725; PMCID: PMC8574048
Breast cancer dormancy is associated with a 4NG1 state and not senescence.

Prunier C, Alay A, van Dijk M, Ammerlaan KL, van Gelderen S, Marvin DL, Teunisse A, Slieker RC, Szuhai K, Jochemsen AG, Solé X, Ten Dijke P, Ritsma L. NPJ Breast Cancer. 2021 Oct 27;7(1):140. doi: 10.1038/s41523-021-00347-0. Epub: 2021 Oct 27. PMID: 34707097; PMCID: PMC8551199
Relationship between the Risk of Gastric Cancer and Adherence to the Mediterranean Diet According to Different Estimators. MCC-Spain Study.

Álvarez-Álvarez L, Vitelli-Storelli F, Rubín-García M, Aragonés N, Ardanaz E, Castaño-Vinyals G, Obón-Santacana M, Dierssen-Sotos T, Salas-Trejo D, Tardón A, Moleón JJJ, Alguacil J, Chirlaque MD, Pérez-Gómez B, Pollán M, Kogevinas M, Martín V. Cancers (Basel). 2021 Oct 21;13(21). doi: 10.3390/cancers13215281. Epub: 2021 Oct 21. PMID: 34771444; PMCID: PMC8582518
Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies.

Julián-Serrano S, Yuan F, Wheeler W, Benyamin B, Machiela MJ, Arslan AA, Beane-Freeman LE, Bracci PM, Duell EJ, Du M, Gallinger S, Giles GG, Goodman PJ, Kooperberg C, Marchand LL, Neale RE, Shu XO, Van Den Eeden SK, Visvanathan K, Zheng W, Albanes D, Andreotti G, Ardanaz E, Babic A, Berndt SI, Brais LK, Brennan P, Bueno-de-Mesquita B, Buring JE, Chanock SJ, Childs EJ, Chung CC, Fabiánová E, Foretová L, Fuchs CS, Gaziano JM, Gentiluomo M, Giovannucci EL, Goggins MG, Hackert T, Hartge P, Hassan MM, Holcátová I, Holly EA, Hung RI, Janout V, Kurtz RC, Lee IM, Malats N, McKean D, Milne RL, Newton CC, Oberg AL, Perdomo S, Peters U, Porta M, Rothman N, Schulze MB, Sesso HD, Silverman DT, Thompson IM, Wactawski-Wende J, Weiderpass E, Wenstzensen N, White E, Wilkens LR, Yu H, Zeleniuch-Jacquotte A, Zhong J, Kraft P, Li D, Campbell PT, Petersen GM, Wolpin BM, Risch HA, Amundadottir LT, Klein AP, Yu K, Stolzenberg-Solomon RZ. Am J Clin Nutr. 2021 Oct 4;114(4):1408-1417. doi: 10.1093/ajcn/nqab217. PMID: 34258619; PMCID: PMC8488877
Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis.

Wang L, Wang E, Prado Balcazar J, Wu Z, Xiang K, Wang Y, Huang Q, Negrete M, Chen KY, Li W, Fu Y, Dohlman A, Mines R, Zhang L, Kobayashi Y, Chen T, Shi G, Shen JP, Kopetz S, Tata PR, Moreno V, Gersbach C, Crawford G, Hsu D, Huang E, Bu P, Shen X. Adv Sci (Weinh). 2021 Oct;8(19):e2004673. doi: 10.1002/advs.202004673. Epub: 2021 Aug 10. PMID: 34378358; PMCID: PMC8498885
Gene Expression Profiling as a Potential Tool for Precision Oncology in Non-Small Cell Lung Cancer.

Hijazo-Pechero S, Alay A, Marín R, Vilariño N, Muñoz-Pinedo C, Villanueva A, Santamaría D, Nadal E, Solé X. Cancers (Basel). 2021 Sep 22;13(19). doi: 10.3390/cancers13194734. Epub: 2021 Sep 22. PMID: 34638221; PMCID: PMC8507534
Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoids.

Devall M, Dampier CH, Eaton S, Ali MW, Díez-Obrero V, Moratalla-Navarro F, Bryant J, Jennelle LT, Moreno V, Powell SM, Peters U, Casey G. Oncotarget. 2021 Sep 14;12(19):1863-1877. doi: 10.18632/oncotarget.28058. Epub: 2021 Sep 14. PMID: 34548904; PMCID: PMC8448508
Reply to: Extended adjuvant temozolomide in newly diagnosed glioblastoma: the more, the better?

Balana C, Sun C, Vaz MA, Esteve A. Neuro Oncol. 2021 Sep 1;23(9):1616-1618. doi: 10.1093/neuonc/noab125. PMID: 34244800; PMCID: PMC8408847
Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue.

Díez-Villanueva A, Jordà M, Carreras-Torres R, Alonso H, Cordero D, Guinó E, Sanjuan X, Santos C, Salazar R, Sanz-Pamplona R, Moreno V. Clin Epigenetics. 2021 Aug 21;13(1):162. doi: 10.1186/s13148-021-01148-9. Epub: 2021 Aug 21. PMID: 34419169; PMCID: PMC8380335
Non-Lynch Familial and Early-Onset Colorectal Cancer Explained by Accumulation of Low-Risk Genetic Variants.

Mur P, Bonifaci N, Díez-Villanueva A, Munté E, Alonso MH, Obón-Santacana M, Aiza G, Navarro M, Piñol V, Brunet J, Tomlinson I, Capellá G, Moreno V, Valle L. Cancers (Basel). 2021 Jul 31;13(15). doi: 10.3390/cancers13153857. Epub: 2021 Jul 31. PMID: 34359758; PMCID: PMC8345397
Genetic architectures of proximal and distal colorectal cancer are partly distinct.

Huyghe JR, Harrison TA, Bien SA, Hampel H, Figueiredo JC, Schmit SL, Conti DV, Chen S, Qu C, Lin Y, Barfield R, Baron JA, Cross AJ, Diergaarde B, Duggan D, Harlid S, Imaz L, Kang HM, Levine DM, Perduca V, Perez-Cornago A, Sakoda LC, Schumacher FR, Slattery ML, Toland AE, van Duijnhoven FJB, Van Guelpen B, Agudo A, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Banbury BL, Bassik MC, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Boutron-Ruault MC, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Caan BJ, Campbell PT, Carr PR, Castells A, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Curtis KR, de la Chapelle A, Easton DF, English DR, Feskens EJM, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Jenab M, Jenkins MA, Joshi AD, Keku TO, Kooperberg C, Kühn T, Küry S, Le Marchand L, Lejbkowicz F, Li CI, Li L, Lieb W, Lindblom A, Lindor NM, Männistö S, Markowitz SD, Milne RL, Moreno L, Murphy N, Nassir R, Offit K, Ogino S, Panico S, Parfrey PS, Pearlman R, Pharoah PDP, Phipps AI, Platz EA, Potter JD, Prentice RL, Qi L, Raskin L, Rennert G, Rennert HS, Riboli E, Schafmayer C, Schoen RE, Seminara D, Song M, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Trichopoulou A, Ulrich CM, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Wolk A, Woods MO, Wu AH, Abecasis GR, Nickerson DA, Scacheri PC, Kundaje A, Casey G, Gruber SB, Hsu L, Moreno V, Hayes RB, Newcomb PA, Peters U. Gut. 2021 Jul;70(7):1325-1334. doi: 10.1136/gutjnl-2020-321534. Epub: 2021 Feb 25. PMID: 33632709; PMCID: PMC8223655
Positive impact of a faecal-based screening programme on colorectal cancer mortality risk.

Ibáñez-Sanz G, Milà N, Vidal C, Rocamora J, Moreno V, Sanz-Pamplona R, Garcia M, MSIC-SC research group. PLoS One. 2021;16(6):e0253369. doi: 10.1371/journal.pone.0253369. Epub: 2021 Jun 30. PMID: 34191813; PMCID: PMC8244848
Association Between Smoking and Molecular Subtypes of Colorectal Cancer.

Wang X, Amitay E, Harrison TA, Banbury BL, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Cao Y, Chan AT, Chang-Claude J, Gallinger SJ, Giannakis M, Giles GG, Gunter MJ, Hopper JL, Jenkins MA, Lin Y, Moreno V, Nishihara R, Newcomb PA, Ogino S, Phipps AI, Sakoda LC, Schoen RE, Slattery ML, Song M, Sun W, Thibodeau SN, Toland AE, Van Guelpen B, Woods MO, Hsu L, Hoffmeister M, Peters U. JNCI Cancer Spectr. 2021 Aug;5(4). doi: 10.1093/jncics/pkab056. Epub: 2021 Jun 14. PMID: 34377935; PMCID: PMC8346704
Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.

Papantoniou K, Castaño-Vinyals G, Espinosa A, Turner MC, Martín-Sánchez V, Casabonne D, Aragonés N, Gómez-Acebo I, Ardanaz E, Jimenez-Moleon JJ, Amiano P, Molina-Barceló A, Alguacil J, Fernández-Tardón G, Huerta JM, Hernández-Segura N, Perez-Gomez B, Llorca J, Vidán-Alli J, Olmedo-Requena R, Gil L, Castañon-López C, Pollan M, Kogevinas M, Moreno V. Sci Rep. 2021 Jun 3;11(1):11822. doi: 10.1038/s41598-021-91275-3. Epub: 2021 Jun 3. PMID: 34083698; PMCID: PMC8175745
Risk of gastric cancer in the environs of industrial facilities in the MCC-Spain study.

García-Pérez J, Lope V, Fernández de Larrea-Baz N, Molina AJ, Tardón A, Alguacil J, Pérez-Gómez B, Moreno V, Guevara M, Castaño-Vinyals G, Jiménez-Moleón JJ, Gómez-Acebo I, Molina-Barceló A, Martín V, Kogevinas M, Pollán M, Aragonés N. Environ Pollut. 2021 Jun 1;278():116854. doi: 10.1016/j.envpol.2021.116854. Epub: 2021 Mar 3. PMID: 33714062
TP53, a gene for colorectal cancer predisposition in the absence of Li-Fraumeni-associated phenotypes.

Terradas M, Mur P, Belhadj S, Woodward ER, Burghel GJ, Munoz-Torres PM, Quintana I, Navarro M, Brunet J, Lazaro C, Pineda M, Moreno V, Capella G, Evans DGR, Valle L. Gut. 2021 Jun;70(6):1139-1146. doi: 10.1136/gutjnl-2020-321825. Epub: 2020 Sep 30. PMID: 32998877
Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3.

Mocci E, Kundu P, Wheeler W, Arslan AA, Beane-Freeman LE, Bracci PM, Brennan P, Canzian F, Du M, Gallinger S, Giles GG, Goodman PJ, Kooperberg C, Le Marchand L, Neale RE, Shu XO, Visvanathan K, White E, Zheng W, Albanes D, Andreotti G, Babic A, Bamlet WR, Berndt SI, Blackford AL, Bueno-de-Mesquita B, Buring JE, Campa D, Chanock SJ, Childs EJ, Duell EJ, Fuchs CS, Gaziano JM, Giovannucci EL, Goggins MG, Hartge P, Hassan MM, Holly EA, Hoover RN, Hung RJ, Kurtz RC, Lee IM, Malats N, Milne RL, Ng K, Oberg AL, Panico S, Peters U, Porta M, Rabe KG, Riboli E, Rothman N, Scelo G, Sesso HD, Silverman DT, Stevens VL, Strobel O, Thompson IM Jr, Tjonneland A, Trichopoulou A, Van Den Eeden SK, Wactawski-Wende J, Wentzensen N, Wilkens LR, Yu H, Yuan F, Zeleniuch-Jacquotte A, Amundadottir LT, Li D, Jacobs EJ, Petersen GM, Wolpin BM, Risch HA, Kraft P, Chatterjee N, Klein AP, Stolzenberg-Solomon R. Cancer Res. 2021 Jun 1;81(11):3134-3143. doi: 10.1158/0008-5472.CAN-20-3267. Epub: 2021 Feb 11. PMID: 33574088; PMCID: PMC8178175
Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.

Tsilidis KK, Papadimitriou N, Dimou N, Gill D, Lewis SJ, Martin RM, Murphy N, Markozannes G, Zuber V, Cross AJ, Burrows K, Lopez DS, Key TJ, Travis RC, Perez-Cornago A, Hunter DJ, van Duijnhoven FJB, Albanes D, Arndt V, Berndt SI, Bézieau S, Bishop DT, Boehm J, Brenner H, Burnett-Hartman A, Campbell PT, Casey G, Castellví-Bel S, Chan AT, Chang-Claude J, de la Chapelle A, Figueiredo JC, Gallinger SJ, Giles GG, Goodman PJ, Gsur A, Hampe J, Hampel H, Hoffmeister M, Jenkins MA, Keku TO, Kweon SS, Larsson SC, Le Marchand L, Li CI, Li L, Lindblom A, Martín V, Milne RL, Moreno V, Nan H, Nassir R, Newcomb PA, Offit K, Pharoah PDP, Platz EA, Potter JD, Qi L, Rennert G, Sakoda LC, Schafmayer C, Slattery ML, Snetselaar L, Schenk J, Thibodeau SN, Ulrich CM, Van Guelpen B, Harlid S, Visvanathan K, Vodickova L, Wang H, White E, Wolk A, Woods MO, Wu AH, Zheng W, Bueno-de-Mesquita B, Boutron-Ruault MC, Hughes DJ, Jakszyn P, Kühn T, Palli D, Riboli E, Giovannucci EL, Banbury BL, Gruber SB, Peters U, Gunter MJ. Am J Clin Nutr. 2021 Jun 1;113(6):1490-1502. doi: 10.1093/ajcn/nqab003. PMID: 33740060; PMCID: PMC8168352
Predicting MHC I restricted T cell epitopes in mice with NAP-CNB, a novel online tool.

Wert-Carvajal C, Sánchez-García R, Macías JR, Sanz-Pamplona R, Pérez AM, Alemany R, Veiga E, Sorzano CÓS, Muñoz-Barrutia A. Sci Rep. 2021 May 24;11(1):10780. doi: 10.1038/s41598-021-89927-5. Epub: 2021 May 24. PMID: 34031450; PMCID: PMC8144223
Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer.

Archambault AN, Lin Y, Jeon J, Harrison TA, Bishop DT, Brenner H, Casey G, Chan AT, Chang-Claude J, Figueiredo JC, Gallinger S, Gruber SB, Gunter MJ, Hoffmeister M, Jenkins MA, Keku TO, Marchand LL, Li L, Moreno V, Newcomb PA, Pai R, Parfrey PS, Rennert G, Sakoda LC, Sandler RS, Slattery ML, Song M, Win AK, Woods MO, Murphy N, Campbell PT, Su YR, Zeleniuch-Jacquotte A, Liang PS, Du M, Hsu L, Peters U, Hayes RB. JNCI Cancer Spectr. 2021 Jun;5(3). doi: 10.1093/jncics/pkab029. Epub: 2021 May 20. PMID: 34041438; PMCID: PMC8134523
Coffee consumption and colorectal cancer risk: a multicentre case-control study from Italy and Spain.

Rosato V, Guercio V, Bosetti C, Gracia-Lavedan E, Villanueva CM, Polesel J, Toffoluti F, Moreno V, Martin V, Aragonés N, Dierssen-Sotos T, Olmedo-Requena R, Guevara M, Amiano P, Salas D, Fernandez-Tardon G, Alguacil J, Chirlaque López MD, Fernandez-Villa T, Pérez-Gómez B, Gomez-Acebo I, Jiménez-Moleón JJ, Moreno-Iribas C, José Molina A, Castaño Vinyals G, Pollan M, Kogevinas M, La Vecchia C, Tavani A. Eur J Cancer Prev. 2021 May 1;30(3):204-210. doi: 10.1097/CEJ.0000000000000593. PMID: 33783378
Multi-omics analysis to identify susceptibility genes for colorectal cancer.

Yuan Y, Bao J, Chen Z, Villanueva AD, Wen W, Wang F, Zhao D, Fu X, Cai Q, Long J, Shu XO, Zheng D, Moreno V, Zheng W, Lin W, Guo X. Hum Mol Genet. 2021 Apr 27;30(5):321-330. doi: 10.1093/hmg/ddab021. PMID: 33481017; PMCID: PMC8485221
Common gene variants within 3'-untranslated regions as modulators of multiple myeloma risk and survival.

Melaiu O, Macauda A, Sainz J, Calvetti D, Facioni MS, Maccari G, Ter Horst R, Netea MG, Li Y, Grząśko N, Moreno V, Jurczyszyn A, Jerez A, Watek M, Varkonyi J, Garcia-Sanz R, Kruszewski M, Dudziński M, Kadar K, Jacobsen SEH, Mazur G, Andersen V, Rybicka M, Zawirska D, Raźny M, Zaucha JM, Ostrovsky O, Iskierka-Jazdzewska E, Reis RM, Stępień A, Beider K, Nagler A, Druzd-Sitek A, Marques H, Martìnez-Lopez J, Lesueur F, Avet-Loiseau H, Vangsted AJ, Krawczyk-Kulis M, Butrym A, Jamroziak K, Dumontet C, Vogel U, Rymko M, Pelosini M, Subocz E, Szombath G, Sarasquete ME, Silvestri R, Morani F, Landi S, Campa D, Canzian F, Gemignani F. Int J Cancer. 2021 Apr 15;148(8):1887-1894. doi: 10.1002/ijc.33377. Epub: 2020 Nov 20. PMID: 33152124
Genetically determined telomere length and multiple myeloma risk and outcome.

Giaccherini M, Macauda A, Orciuolo E, Rymko M, Gruenpeter K, Dumontet C, Raźny M, Moreno V, Buda G, Beider K, Varkonyi J, Avet-Loiseau H, Martinez-Lopez J, Marques H, Watek M, Sarasquete ME, Andersen V, Karlin L, Suska A, Kruszewski M, Abildgaard N, Dudziński M, Butrym A, Nagler A, Vangsted AJ, Kadar K, Waldemar T, Jamroziak K, Jacobsen SEH, Ebbesen LH, Taszner M, Mazur G, Lesueur F, Pelosini M, Garcia-Sanz R, Jurczyszyn A, Demangel D, Reis RM, Iskierka-Jażdżewska E, Markiewicz M, Gemignani F, Subocz E, Zawirska D, Druzd-Sitek A, Stępień A, Alonso MH, Sainz J, Canzian F, Campa D. Blood Cancer J. 2021 Apr 14;11(4):74. doi: 10.1038/s41408-021-00462-y. Epub: 2021 Apr 14. PMID: 33854038; PMCID: PMC8046773
Consumption of ultra-processed foods and drinks and colorectal, breast, and prostate cancer.

Romaguera D, Fernández-Barrés S, Gracia-Lavedán E, Vendrell E, Azpiri M, Ruiz-Moreno E, Martín V, Gómez-Acebo I, Obón M, Molinuevo A, Fresán U, Molina-Barceló A, Olmedo-Requena R, Tardón A, Alguacil J, Solans M, Huerta JM, Ruiz-Dominguez JM, Aragonés N, Fernández-Villa T, Dierssen-Sotos T, Moreno V, Guevara M, Vanaclocha-Espi M, Lozano-Lorca M, Fernández-Tardón G, Castaño-Vinyals G, Pérez-Gómez B, Molina AJ, Llorca J, Gil L, Castilla J, Pollán M, Kogevinas M, Amiano P. Clin Nutr. 2021 Apr;40(4):1537-1545. doi: 10.1016/j.clnu.2021.02.033. Epub: 2021 Feb 27. PMID: 33743289
Circulating adipokine concentrations and risk of five obesity-related cancers: A Mendelian randomization study.

Dimou NL, Papadimitriou N, Mariosa D, Johansson M, Brennan P, Peters U, Chanock SJ, Purdue M, Bishop DT, Gago-Dominquez M, Giles GG, Moreno V, Platz EA, Tangen CM, Wolk A, Zheng W, Wu X, Campbell PT, Giovannucci E, Lin Y, CCFR, Endometrial Cancer Association Consortium, Gunter MJ, Murphy N. Int J Cancer. 2021 Apr 1;148(7):1625-1636. doi: 10.1002/ijc.33338. Epub: 2020 Oct 26. PMID: 33038280; PMCID: PMC7894468
Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study).

Weitzer J, Castaño-Vinyals G, Aragonés N, Gómez-Acebo I, Guevara M, Amiano P, Martín V, Molina-Barceló A, Alguacil J, Moreno V, Suarez-Calleja C, Jiménez-Moleón JJ, Marcos-Gragera R, Papantoniou K, Pérez-Gómez B, Llorca J, Ascunce N, Gil L, Gracia-Lavedan E, Casabonne D, Lope V, Pollán M, Kogevinas M. Int J Cancer. 2021 Mar 15;148(6):1360-1371. doi: 10.1002/ijc.33310. Epub: 2020 Oct 7. PMID: 32976649; PMCID: PMC7891656
Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts.

Sainz J, García-Verdejo FJ, Martínez-Bueno M, Kumar A, Sánchez-Maldonado JM, Díez-Villanueva A, Vodičková L, Vymetálková V, Martin Sánchez V, Da Silva Filho MI, Sampaio-Marques B, Brezina S, Butterbach K, Ter Horst R, Hoffmeister M, Ludovico P, Jurado M, Li Y, Sánchez-Rovira P, Netea MG, Gsur A, Vodička P, Moreno V, Hemminki K, Brenner H, Chang-Claude J, Försti A. Cancers (Basel). 2021 Mar 12;13(6). doi: 10.3390/cancers13061258. Epub: 2021 Mar 12. PMID: 33809172; PMCID: PMC7998818
Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse.

Kamal Y, Dwan D, Hoehn HJ, Sanz-Pamplona R, Alonso MH, Moreno V, Cheng C, Schell MJ, Kim Y, Felder SI, Rennert HS, Melas M, Lazaris C, Bonner JD, Siegel EM, Shibata D, Rennert G, Gruber SB, Frost HR, Amos CI, Schmit SL. Oncoimmunology. 2021 Mar 9;10(1):1862529. doi: 10.1080/2162402X.2020.1862529. Epub: 2021 Mar 9. PMID: 33763292; PMCID: PMC7951964
MorbiNet Study: Hypothyroidism Comorbidity Networks in the Adult General Population.

Moratalla-Navarro F, Moreno V, López-Simarro F, Aguado A. J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1179-e1190. doi: 10.1210/clinem/dgaa927. PMID: 33319230
Adequacy of early-stage breast cancer systemic adjuvant treatment to Saint Gallen-2013 statement: the MCC-Spain study.

Gómez-Acebo I, Dierssen-Sotos T, Mirones M, Pérez-Gómez B, Guevara M, Amiano P, Sala M, Molina AJ, Alonso-Molero J, Moreno V, Suarez-Calleja C, Molina-Barceló A, Alguacil J, Marcos-Gragera R, Fernández-Ortiz M, Sanz-Guadarrama O, Castaño-Vinyals G, Gil-Majuelo L, Moreno-Iribas C, Aragonés N, Kogevinas M, Pollán M, Llorca J. Sci Rep. 2021 Mar 8;11(1):5375. doi: 10.1038/s41598-021-84825-2. Epub: 2021 Mar 8. PMID: 33686151; PMCID: PMC7970883
Additive Role of Immune System Infiltration and Angiogenesis in Uveal Melanoma Progression.

García-Mulero S, Alonso MH, Del Carpio LP, Sanz-Pamplona R, Piulats JM. Int J Mol Sci. 2021 Mar 6;22(5). doi: 10.3390/ijms22052669. Epub: 2021 Mar 6. PMID: 33800878; PMCID: PMC7961481
A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer.

Nounu A, Greenhough A, Heesom KJ, Richmond RC, Zheng J, Weinstein SJ, Albanes D, Baron JA, Hopper JL, Figueiredo JC, Newcomb PA, Lindor NM, Casey G, Platz EA, Le Marchand L, Ulrich CM, Li CI, van Duijnhoven FJB, Gsur A, Campbell PT, Moreno V, Vodicka P, Vodickova L, Brenner H, Chang-Claude J, Hoffmeister M, Sakoda LC, Slattery ML, Schoen RE, Gunter MJ, Castellví-Bel S, Kim HR, Kweon SS, Chan AT, Li L, Zheng W, Bishop DT, Buchanan DD, Giles GG, Gruber SB, Rennert G, Stadler ZK, Harrison TA, Lin Y, Keku TO, Woods MO, Schafmayer C, Van Guelpen B, Gallinger S, Hampel H, Berndt SI, Pharoah PDP, Lindblom A, Wolk A, Wu AH, White E, Peters U, Drew DA, Scherer D, Bermejo JL, Williams AC, Relton CL. Cancer Epidemiol Biomarkers Prev. 2021 Mar;30(3):564-575. doi: 10.1158/1055-9965.EPI-20-1176. Epub: 2020 Dec 14. PMID: 33318029; PMCID: PMC8086774
A likelihood ratio approach for identifying three-quarter siblings in genetic databases.

Galván-Femenía I, Barceló-Vidal C, Sumoy L, Moreno V, de Cid R, Graffelman J. Heredity (Edinb). 2021 Mar;126(3):537-547. doi: 10.1038/s41437-020-00392-8. Epub: 2021 Jan 15. PMID: 33452467; PMCID: PMC8027836
Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.

Guo X, Lin W, Wen W, Huyghe J, Bien S, Cai Q, Harrison T, Chen Z, Qu C, Bao J, Long J, Yuan Y, Wang F, Bai M, Abecasis GR, Albanes D, Berndt SI, Bézieau S, Bishop DT, Brenner H, Buch S, Burnett-Hartman A, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Cho SH, Conti DV, Chapelle A, Feskens EJM, Gallinger SJ, Giles GG, Goodman PJ, Gsur A, Guinter M, Gunter MJ, Hampe J, Hampel H, Hayes RB, Hoffmeister M, Kampman E, Kang HM, Keku TO, Kim HR, Le Marchand L, Lee SC, Li CI, Li L, Lindblom A, Lindor N, Milne RL, Moreno V, Murphy N, Newcomb PA, Nickerson DA, Offit K, Pearlman R, Pharoah PDP, Platz EA, Potter JD, Rennert G, Sakoda LC, Schafmayer C, Schmit SL, Schoen RE, Schumacher FR, Slattery ML, Su YR, Tangen CM, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Wang X, White E, Wolk A, Woods MO, Casey G, Hsu L, Jenkins MA, Gruber SB, Peters U, Zheng W. Gastroenterology. 2021 Mar;160(4):1164-1178.e6. doi: 10.1053/j.gastro.2020.08.062. Epub: 2020 Oct 12. PMID: 33058866; PMCID: PMC7956223
Tumor-Associated Microbiome: Where Do We Stand?

Oliva M, Mulet-Margalef N, Ochoa-De-Olza M, Napoli S, Mas J, Laquente B, Alemany L, Duell EJ, Nuciforo P, Moreno V. Int J Mol Sci. 2021 Feb 1;22(3). doi: 10.3390/ijms22031446. Epub: 2021 Feb 1. PMID: 33535583; PMCID: PMC7867144
Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer.

Sun R, Xu M, Li X, Gaynor S, Zhou H, Li Z, Bossé Y, Lam S, Tsao MS, Tardon A, Chen C, Doherty J, Goodman G, Bojesen SE, Landi MT, Johansson M, Field JK, Bickeböller H, Wichmann HE, Risch A, Rennert G, Arnold S, Wu X, Melander O, Brunnström H, Le Marchand L, Liu G, Andrew A, Duell E, Kiemeney LA, Shen H, Haugen A, Johansson M, Grankvist K, Caporaso N, Woll P, Dawn Teare M, Scelo G, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Albanes D, Mak R, Barbie D, Brennan P, Hung RJ, Amos CI, Christiani DC, Lin X. Genet Epidemiol. 2021 Feb;45(1):99-114. doi: 10.1002/gepi.22358. Epub: 2020 Sep 14. PMID: 32924180; PMCID: PMC7855632
Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study.

Hinchliffe A, Kogevinas M, Pérez-Gómez B, Ardanaz E, Amiano P, Marcos-Delgado A, Castaño-Vinyals G, Llorca J, Moreno V, Alguacil J, Fernandez-Tardón G, Salas D, Marcos-Gragera R, Aragonés N, Guevara M, Gil L, Martin V, Benavente Y, Gomez-Acebo I, Santibáñez M, Ángel Alba M, García AM, Pollán M, Turner MC. Cancer Epidemiol Biomarkers Prev. 2021 Feb;30(2):364-372. doi: 10.1158/1055-9965.EPI-20-0732. Epub: 2020 Dec 2. PMID: 33268491
Integrative transcriptome analysis of malignant pleural mesothelioma reveals a clinically relevant immune-based classification.

Alay A, Cordero D, Hijazo-Pechero S, Aliagas E, Lopez-Doriga A, Marín R, Palmero R, Llatjós R, Escobar I, Ramos R, Padrones S, Moreno V, Nadal E, Solé X. J Immunother Cancer. 2021 Feb;9(2). doi: 10.1136/jitc-2020-001601. PMID: 33632900; PMCID: PMC7908918
RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma.

Esteve-Codina A, Alameda F, Carrato C, Pineda E, Arpí O, Martinez-García M, Mallo M, Gut M, Dabad M, Tortosa A, Del Barco S, Capellades J, Puig J, Gallego O, Pujol T, Oleaga L, Gil-Gil M, de Quintana-Schmidt C, Valduvieco I, Martinez-Cardús A, Bellosillo B, Muñoz-Marmol AM, Esteve A, Domenech M, Camins A, Craven-Bartle J, Villa S, Marruecos J, Domenech S, de la Iglesia N, Balana C. Clin Cancer Res. 2021 Jan 15;27(2):645-655. doi: 10.1158/1078-0432.CCR-20-2141. Epub: 2020 Oct 26. PMID: 33106291
New advances in the clinical management of RAS and BRAF mutant colorectal cancer patients.

Ruffinelli JC, Santos Vivas C, Sanz-Pamplona R, Moreno V. Expert Rev Gastroenterol Hepatol. 2021 Jan;15(1):65-79. doi: 10.1080/17474124.2021.1826305. Epub: 2020 Oct 12. PMID: 32946312
Proton-pump inhibitors are associated with a high false-positivity rate in faecal immunochemical testing.

Ibáñez-Sanz G, Milà N, de la Peña-Negro LC, Garcia M, Vidal C, Rodríguez-Alonso L, Binefa G, Rodríguez-Moranta F, Moreno V. J Gastroenterol. 2021 Jan;56(1):42-53. doi: 10.1007/s00535-020-01738-z. Epub: 2020 Nov 7. PMID: 33159805
Genetic Effects on Transcriptome Profiles in Colon Epithelium Provide Functional Insights for Genetic Risk Loci.

Díez-Obrero V, Dampier CH, Moratalla-Navarro F, Devall M, Plummer SJ, Díez-Villanueva A, Peters U, Bien S, Huyghe JR, Kundaje A, Ibáñez-Sanz G, Guinó E, Obón-Santacana M, Carreras-Torres R, Casey G, Moreno V. Cell Mol Gastroenterol Hepatol. 2021;12(1):181-197. doi: 10.1016/j.jcmgh.2021.02.003. Epub: 2021 Feb 16. PMID: 33601062; PMCID: PMC8102177