Publicacions 2026

1. LARP1 integrates MYC and mTOR signaling to enable anabolic growth during tumor initiation.

   Fuentes P, Iannizzotto F, Battaglia E, Balzamo C, Tola C, Forcada B, Bosch-I-Crespo P, Morón-Duran FD, Frank BE, Martínez-Herráez C, Mastora Z, Manfili-Marinho G, Tauler A, Santos C, Salazar R, Gentilella A. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2523043123. doi: 10.1073/pnas.2523043123. Epub: 2026 Jun 12. PMID: 42284331

2. Optimisation and Validation of a Quantitative Method for the Analysis of Polymers of Nanoplastics in Human Faeces.

   Torres E, Obon M, Moreno V, Moratalla-Navarro F, Esquena J, Llorca M, Farré M. Molecules. 2026 Jun 4;31(11). doi: 10.3390/molecules31111947. Epub: 2026 Jun 4. PMID: 42280250; PMCID: PMC13257795

3. Consistent Metabolomic and Genetic Evidence Supports Acisoga as a Key Contributor to Colorectal Neoplasia Progression.

   Rius-Sansalvador B, Chatziioannou AC, Keski-Rahkonen P, Robinot NR, Moratalla-Navarro F, Moragas N, Guinó E, Jenab M, Morón-Duran FD, Atencia C, Ibáñez-Sanz G, Rodríguez-Alonso L, Mata A, García-Rodríguez A, Noh H, Fryer E, Zamora-Ros R, Mokoroa O, Delfrade I, Caini S, Huerta JM, Truong T, Severi G, Asgari Y, Tumino R, Panico S, Tjønneland A, Rostgaard-Hansen AL, Sánchez MJ, Pala V, Ricceri F, Gunter MJ, Moreno V, Obón-Santacana M. Cancer Epidemiol Biomarkers Prev. 2026 May 27;(). doi: 10.1158/1055-9965.EPI-25-2050. Epub: 2026 May 27. PMID: 42201318

4. Implementing a molecular prescreening strategy for tumors without public NGS access in a cancer center network: Results from the PREICO project.

   Sàbat P, Ajenjo-Bauza M, Hierro C, Ruffinelli JC, Gil-Martin M, Ochoa-de-Olza M, Bergamino M, Calvo M, Soto-Castillo JJ, Fina C, Llop S, Stradella A, Oliva M, Notario L, Carcereny E, Teixidor-Vilà E, Domènech M, Jové M, Villanueva R, Alay A, Azuara D, González-Acosta M, Otero-Torres S, Gausachs M, Varela M, Villatoro S, Solanes A, Teulé A, Cuadra C, Moreno V, Nadal E, Cordero D, Lázaro C, Martin-Liberal J. Eur J Cancer. 2026 May 15;239():116728. doi: 10.1016/j.ejca.2026.116728. Epub: 2026 Apr 4. PMID: 41962211

5. Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses.

   Chalitsios CV, Chan WC, Markozannes G, Aglago EK, Berndt SI, Buchanan DD, Campbell PT, Cao Y, Dimou N, Drew DA, French AJ, Gallinger S, Georgeson P, Giannakis M, Gruber SB, Gunter MJ, Harrison TA, Brenner H, Hoffmeister M, Urruchúa-Rodríguez MJ, Hsu L, Huang WY, Hullar MA, Huyghe JR, Jenkins MA, Jayasekara H, Moreno V, Newton CC, Nowak JA, Obón-Santacana M, Ogino S, Pellatt AJ, Peoples A, Qu C, Schmit SL, Steinfelder RS, Sun W, Thomas CE, Toland AE, Trinh QM, Ugai T, Um CY, Van Guelpen B, Zaidi SH, Peters U, Phipps AI, Tsilidis KK. Am J Clin Nutr. 2026 Apr 22;():101308. doi: 10.1016/j.ajcnut.2026.101308. Epub: 2026 Apr 22. PMID: 42031341

6. Development and validation of an epidemiological risk score for early detection of pancreatic cancer in high-risk individuals within the IMAGene project.

   Riobó-Mayo L, Salvador L, Teulé A, Guinó E, Layos L, Oliveri S, Cincidda C, Ongaro G, Accornero CA, Cella CA, Gervaso L, Fazio N, Summers PE, Petralia G, Canivet C, Bournet B, Buscail L, Roman A, Balacescu L, Trifa A, Catana A, Pop F, Balacescu O, Przybylowicz P, Taryma-Lesniak O, Wojdacz TK, Obón-Santacana M, Moreno V. Int J Epidemiol. 2026 Apr 17;55(3). doi: 10.1093/ije/dyag064. PMID: 42160519

7. Sex differences in the colorectal tumor-associated T cell responses.

   Seitz E, Tsai YY, Sanz-Pamplona R, Melas M, Walker CP, Bonner JD, McDonnell KJ, Idos GE, Greenson JK, Rennert G, Moreno V, Gruber SB, Schmit SL. Cancer Epidemiol Biomarkers Prev. 2026 Apr 8;(). doi: 10.1158/1055-9965.EPI-25-1579. Epub: 2026 Apr 8. PMID: 41949638

8. TGF-B-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method.

   Sanchez Mendez J, Queme B, Fu Y, Morrison JL, Lewinger JP, Kawaguchi ES, Mi H, Obón-Santacana M, Moratalla-Navarro F, Martín V, Moreno V, Qu C, Huyghe JR, Newcomb PA, Phipps AI, Thomas CE, Conti DV, Wang J, Platz EA, Visvanathan K, Keku TO, Newton CC, Um CY, Kundaje A, Gunter MJ, Dimou N, Papadimitriou N, van Duijnhoven FJB, Männistö S, Rennert G, Wolk A, Hoffmeister M, Brenner H, Tian Y, Le Marchand L, Bouras E, Tsilidis KK, Bishop DT, Maclnnis RJ, Buchanan DD, Ulrich CM, Peoples AR, Pellatt A, Li L, Devall MA, Albanes D, Berndt SI, Gruber SB, Ruiz-Narvaez E, Song M, Drew DA, Chan AT, Giannakis M, Hsu L, Peters U, Stern MC, Gauderman WJ. Cancer Epidemiol Biomarkers Prev. 2026 Apr 1;(). doi: 10.1158/1055-9965.EPI-25-1754. Epub: 2026 Apr 1. PMID: 41920173

9. Optimizing GRIDSS for clinical use: A targeted NGS filtering strategy for germline structural variant detection.

   Munté E, Rofes P, Millán-Castillo M, Solanes A, Muñoz X, Campos O, Alay A, Ajenjo-Bauza M, Navarro E, de la Morena-Barrio B, Salinas M, Vargas-Parra G, Cuesta R, Moreno-Cabrera JM, Cordero D, Pineda M, Del Valle J, Lázaro C, Feliubadaló L. Eur J Hum Genet. 2026 Mar 16;(). doi: 10.1038/s41431-026-02016-x. Epub: 2026 Mar 16. PMID: 41840221

10. Association between arsenic levels in toenails and urine and prostate cancer risk: Findings from the MCC-Spain study.

    Varea-Jiménez E, Pastor-Barriuso R, Sierra Á, Dierssen-Sotos T, Fernández Tardón G, Aragonés N, Gómez-Acebo I, Castaño-Vinyals G, Gómez-Ariza JL, Kogevinas M, Moreno V, Fernández-Navarro P, Pollán M, Pérez-Gómez B, García-Esquinas E. Environ Res. 2026 Mar 15;293():123767. doi: 10.1016/j.envres.2026.123767. Epub: 2026 Jan 12. PMID: 41534579

11. ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance.

    Sánchez-Maldonado JM, Macauda A, Cabrera-Serrano AJ, Thomsen H, Güler M, Horst RT, van Guelpen B, Vodicka P, Landi S, Chattopadhyay S, Unal P, Ruiz-Durán L, Casabonne D, Goldschmidt H, Serin I, Carretero-Fernández M, Cabezudo E, Reyes-Zurita F, Norman AD, García-Sanz R, Capurso G, Hoffmann P, Pettersson-Kymmer U, Jiménez-Romera F, Rajkumar SV, Weinhold N, Vodickova L, Langer C, Stein A, Karismaz A, Moreno V, Nöthen MM, Jöckel KH, Tavano F, Martínez-López J, Kumar SK, Gutiérrez-Bautista JF, Basso D, Späth F, Benavente Y, Hildebrandt MAT, Schmidt B, Sevcikova T, Reis RMV, Li Y, López-Nevot MÁ, Netea MG, Campa D, Clay-Gilmour A, Slager SL, Hemminki K, Vachon CM, Försti A, Canzian F, Sainz J. Int J Cancer. 2026 Mar 11;(). doi: 10.1002/ijc.70427. Epub: 2026 Mar 11. PMID: 41813586

12. Integrating circulating microRNAs with epidemiological factors enhances breast cancer detection across subtypes: the MCC-Spain study.

    Gómez-Acebo I, Valero-Dominguez S, Llorca J, Alonso-Molero J, Belmonte T, Castaño-Vinyals G, Moreno V, Romaguera A, Amiano P, Alguacil J, Martín V, Pérez-Gómez B, Burgui R, Molina-Barceló A, Rodríguez-Cundín P, Kogevinas M, Pollán M, Dierssen-Sotos T. Sci Rep. 2026 Mar 7;16(1). doi: 10.1038/s41598-026-41660-7. Epub: 2026 Mar 7. PMID: 41792206; PMCID: PMC13083989

13. HLA Heterozygosity Influences Colorectal Cancer Risk and Survival Outcome.

    Tsai YY, Thomas CE, Law PJ, Chen Z, Gruber SB, Schmit SL, International Colorectal Cancer GWAS Collaborative. Gastroenterology. 2026 Mar;170(3):619-622. doi: 10.1053/j.gastro.2025.10.020. Epub: 2026 Jan 20. PMID: 41556857; PMCID: PMC13010477

14. Association of germline variants with KRAS-mutation status in colorectal cancer.

    Tjader NP, Ramroop J, Gandhi T, Dauch C, Meadows O, Stevens P, Pearlman R, Hampel H, Aglago EK, Berndt SI, Bloomer A, Brenner H, Buchanan DD, Campbell PT, Cao Y, Chan AT, Cheng I, Dimou N, Drew DA, French AJ, Georgeson P, Giannakis M, Giles GG, Gomez M, Gruber SB, Hoffmeister M, Huang WY, Hullar MAJ, Huyghe JR, Loroña N, Moreno V, Newton CC, Nowak JA, Obón-Santacana M, Ogino S, Pellatt A, Peoples AR, Permuth JB, Schmit SL, Schoen RE, Siegel EM, Steinfelder RS, Sun W, Teer JK, Thomas CE, Trinh QM, Tsilidis K, Ugai T, Um CY, Van Guelpen B, Zaidi SH, Figueiredo J, Peters U, Phipps AI, McElroy JP, Toland AE. Sci Rep. 2026 Feb 13;16(1). doi: 10.1038/s41598-026-39644-8. Epub: 2026 Feb 13. PMID: 41688657; PMCID: PMC12982500

15. Genetic risk factors modulate the association between physical activity and colorectal cancer.

    Peoples AR, Obón-Santacana M, Kim AE, Kawaguchi ES, Fu Y, Qu C, Moratalla-Navarro F, Morrison J, Lin Y, Arndt V, Berndt SI, Bien SA, Bishop DT, Bouras E, Brenner H, Buchanan DD, Campbell PT, Chan AT, Chang-Claude J, Conti DV, Corley DA, Devall MA, Dimou N, Drew DA, Gruber SB, Gunter MJ, Harlid S, Harrison TA, Hoffmeister M, Hsu L, Huyghe JR, Keku TO, Kundaje A, Lewinger JP, Li L, Lynch BM, Le Marchand L, Martín V, Murphy N, Newton CC, Ogino S, Hardikar S, Ose J, Pai RK, Palmer JR, Papadimitriou N, Pardamean B, Pellatt AJ, Pinchev M, Platz EA, Potter JD, Rennert G, Ruiz-Narvaez EA, Sakoda LC, Schoen RE, Shcherbina A, Stern MC, Su YR, Thomas CE, Tian Y, Tsilidis KK, Um CY, van Duijnhoven FJB, Van Guelpen B, Visvanathan K, Wang J, White E, Wolk A, Woods MO, Wu AH, Ulrich CM, Peters U, Gauderman WJ, Moreno V. BMC Med. 2026 Feb 5;24(1). doi: 10.1186/s12916-026-04675-5. Epub: 2026 Feb 5. PMID: 41645200; PMCID: PMC12973902

16. The endonuclease MCPIP1 protects against liver cancer development in a sex-dependent manner by modulating B-catenin and CREB1.

    Kwapisz O, Marona P, Gorka J, Myrczek R, Gonzalez-Sanchez E, Bertran E, Kotlinowski J, Gluc M, Alay A, Pydyn N, Kujdowicz M, Ramos E, Fabregat I, Miekus K. JHEP Rep. 2026 Jan 29;8(5):101755. doi: 10.1016/j.jhepr.2026.101755. Epub: 2026 Jan 29. PMID: 41955682; PMCID: PMC13091202

17. Anthropometric Characteristics of Triple-Negative Breast Cancer Patients by Menopausal Status: Evidence from the Population-Based Multicentric Study-MCC-Spain.

    Muñoz-Pérez M, Botella-Juan L, Vitelli-Storelli F, Lope V, Obón-Santacana M, Amiano P, Guevara M, Fernández-Tardón G, Alguacil J, Del Barco S, Molina-Barceló A, Dierssen-Sotos T, Molina AJ, Martín-Sánchez V, Castaño-Vinyals G, Pérez-Gómez B, Kogevinas M, Pollán M, Rubín-García M. Healthcare (Basel). 2026 Jan 27;14(3). doi: 10.3390/healthcare14030321. Epub: 2026 Jan 27. PMID: 41682170; PMCID: PMC12897131

18. Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility.

    Chen Z, Song W, Li Q, Li C, Wen W, Huyghe JR, Law PJ, Fernandez-Rozadilla C, Timofeeva MN, Thomas M, Schmit SL, Martin V, Devall M, Dampier C, Moratalla-Navarro F, Cai Q, Wang J, Shi J, Kweon SS, Tanikawa C, Jia WH, Shu X, Long J, Gao J, Kim J, Shin A, Matsuo K, Jee SH, Jung KJ, Wang N, Kim DH, Ping J, Yang G, Shin MH, Ren Z, Oh JH, Oze I, Ahn YO, Gao YT, Pan ZZ, Kamatani Y, Van Kaer L, Wu L, Li B, Matsuda K, Shu XO, Hsu L, Dunlop MG, Gruber SB, Houlston R, Tomlinson I, Li L, Lau KS, Moreno V, Casey G, Peters U, Zheng W, Guo X. Nat Commun. 2026 Jan 15;17(1):1377. doi: 10.1038/s41467-025-68127-z. Epub: 2026 Jan 15. PMID: 41540004; PMCID: PMC12877115

19. Genome-wide interaction analysis of long-term trihalomethane exposure in drinking water and colorectal cancer risk in a Spanish Multicenter Case-Control Study (MCC-Spain).

    Moratalla-Navarro F, Obón-Santacana M, Rius-Sansalvador B, Guinó E, Moragas N, Donat-Vargas C, de Larrea-Baz NF, Molina-Barceló A, Guevara M, Morón-Duran FD, Dierssen-Sotos T, Tardón A, Castaño-Vinyals G, Cabrera-Castro N, Molina AJ, Aizpurua A, Morales-Suárez-Varela MM, Martín V, Fernández-Navarro P, Villanueva CM, Moreno V. Environ Int. 2026 Jan 11;207():110059. doi: 10.1016/j.envint.2026.110059. Epub: 2026 Jan 11. PMID: 41544563

20. Investigating the Causal Effect of Potential Therapeutic Agents for Colorectal Cancer Prevention: A Mendelian Randomization Analysis.

    Fryer E, Bishop DT, Campbell PT, Chan AT, Le Marchand L, Li CI, Moreno V, Gunter MJ, Phipps AI, Grant RC, Schmit SL, Martin RM, Yarmolinsky J, Haycock P. Cancer Epidemiol Biomarkers Prev. 2026 Jan 9;35(1):95-108. doi: 10.1158/1055-9965.EPI-25-0875. Epub: 2025 oct 14. PMID: 41085561; PMCID: PMC7618373

21. Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention.

    Li Q, Song Q, Chen Z, Choi J, Moreno V, Ping J, Wen W, Li C, Shu X, Yan J, Shu XO, Cai Q, Long J, Huyghe JR, Pai R, Gruber SB, Yang Y, Casey G, Wang X, Toriola AT, Li L, Singh B, Lau KS, Zhou L, Zhang Z, Wu C, Peters U, Zheng W, Long Q, Yin Z, Guo X. Am J Hum Genet. 2026 Jan 8;113(1):41-56. doi: 10.1016/j.ajhg.2025.11.008. Epub: 2025 Dec 2. PMID: 41338217

22. ClinBioNGS: A Clinical Bioinformatics Pipeline for Integrated Analysis of Somatic Next-Generation Sequencing Cancer Panels.

    Marín R, Alay A, Ajenjo-Bauza M, Hijazo-Pechero S, Montironi C, Hernández-Illán E, Jares P, Azuara D, Varela M, Vidal A, Puig-Butillé JA, Lázaro C, Moreno V, Cordero D, Nadal E, Solé X. JCO Clin Cancer Inform. 2026 Jan;10():e2500221. doi: 10.1200/CCI-25-00221. Epub: 2026 Jan 8. PMID: 41505665